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Test Code 4236 Influenza Virus A Antibodies, IgG and IgM (Separate Determinations), Serum

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.25 mL

Collection Instructions: Indicate influenza virus A


Specimen Minimum Volume

0.15 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

IgG: <1:10

IgM: <1:10

Reference values apply to all ages.

Day(s) and Time(s) Performed

Tuesday, Friday; 9 a.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86710 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SFLA Influenza Virus A Ab, IgG, IgM, S In Process

 

Result ID Test Result Name Result LOINC Value
5731 Influenza Virus A Ab, IgG 43837-4
5732 Influenza Virus A Ab, IgM 43838-2

Clinical Information

Influenza is usually a mild illness of the upper respiratory tract. Involvement of the lower respiratory tract, however, can lead to 4 types of clinical syndromes: physical signs of lower respiratory tract involvement without roentgenographic evidence of pneumonia, influenza complicated by bacterial pneumonia, primary influenza virus pneumonia, and combined influenzal and bacterial pneumonias. Incidence of influenza virus infections is seasonal in the United States and usually occurs only from November to March

 

Influenza virus infections are most severe in patients with certain preexisting conditions such as rheumatic heart disease, bronchopulmonary disease, impaired renal function, and diabetes mellitus. Infections can be more severe in elderly patients, pregnant females, and immunocompromised patients.

 

Influenza virus type A can produce serious illness during the first 2 years of life, with croup, bronchitis, and pneumonia being prominent.

 

Influenza A may also precipitate asthmatic attacks and produce chronic pulmonary complications in children.

Interpretation

The presence of IgM class antibody or a 4-fold or greater rise in titer in paired (acute and convalescent) sera indicates recent infection.

 

The presence of IgG class antibody generally indicates past exposure.

Clinical Reference

1. Rothbarth PH, Groen J, Bohnen AM, et al: Influenza virus serology-a comparative study. J Virol Methods 1999;78:163-169

2. Pachucki CT: The diagnosis of influenza. Semin Resp Infect 1992;7:46-53

3. Wendt CH: Community respiratory viruses: organ transplant recipients. Am J Med 1997;102:31-36:42-43

Method Name

Immunofluorescence

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.