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Test Code 2563 P2Y12 Inhibitor (Plavix) Assay

Important Note

Sample must be drawn at a NorthShore Hospital OPL due to limited sample stability. Keep sample at room temperature. Specimen needs to be hand delivered to the lab.

Specimen Containers and Fixatives

Special 2.0 mL Sodium Citrate tube manufacturer by Grainer

Specimen Required

NorthShore Lab Services: patient must present to a NorthShore Hospital Outpatient Laboratory to be drawn.

Hospital setting: submit 4.0 mL blood (2 tubes must be drawn) using second tube method

Day(s) and Time(s) Performed



Reference Values

Patient P2Y12 Reaction Units (PRU) reflects the level of ADP

induced platelet aggregation in the presence of P2Y12 inhibitors.

Interpretation: Patient PRU values <208 indicate platelets are

responsive to anti-P2Y12 medication. PRU values >208 indicate

platelets are unresponsive or insufficiently responsive. Poor

response may be due to many factors, including genetic variation, interfering medications and non-compliance. Patients who have been treated with Glycoprotein IIb/IIIa inhibitor drugs (ReoPro, Integrilin and Tirofiban) should not be tested until platelet function has recovered.

Concordance of PRU and % inhibition results for the VerifyNow

P2Y12 test are shown below.

% Inhibition Threshold PRU Threshold -——————————————————————————- 10% 259 20% 237 30% 214 40% 187 50% 159 60% 131

This data is from the clinical trial by Price et al. Am Heart J.

2009;157:818-824.el. Data and analysis is on file at Accumetrics.

CPT Code Information